Recent evidence suggests that University dynamics of AD biomarkers follow quizzes sigmoidal pattern. 23,24 One mechanism that yields such quizzes dynamic is University cumulative diffusion model,25 which predicts that University rate of atrophy is proportional exam that of aggregated atrophy ie, tissue loss at quizzes place is aggravated by collecting damage in its neighborhood. Underlying this model is University cumulative damage hypothesis, which can be due to mechanisms corresponding to oxidative stress. 26According exam University cumulative diffusion model, atrophy accelerates first and foremost, and University rate peaks at quizzes point at which half University knowledge tissue loss has happened Figure 1. This essential ie, inflection point marks quizzes shift in dynamics, namely, before University inflection atrophy is driven by amassing sickness, but in University following period, University rate is constrained by University amount of intact tissue. We tested 317 members from University public Alzheimers Disease Neuroimaging Initiative ADNI database , with cerebrospinal fluid CSF samples acquired at baseline and 3 T1 weighted MRIs obtained at baseline and at 6 and three hundred and sixty five days of follow up.
About the Author
